SEC INSIDER TRANSACTIONS

REGENERON PHARMACEUTICALS, INC. (REGN) Insider Transactions

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REGN · REGENERON PHARMACEUTICALS, INC.

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Stale snapshot · Covered: filings 2026-05-14 to 2026-10-27 · 8 filings · fetched 2026-10-27T16:21:30Z

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0purchase rows on this page

8sale rows on this page

48matching filing rows

Purchases and sales count original non-derivative P and S rows. Awards, gifts, exercises, derivatives and amendments are shown separately and are not described as market purchases.

Transaction / filed	Reporting owner(s)	Code / security	Quantity	Price as filed	Ownership	Source
2026-10-14Filed 2026-10-15	MURPHY ANDREW JOfficer · Co-Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on May 7, 2026. F2 Represents volume-weighted average price of sales of 14 shares of Company stock on October 14, 2026 at prices ranging from $759.94 to $759.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F3 Represents volume-weighted average price of sales of 74 shares of Company stock on October 14, 2026 at prices ranging from $760.28 to $760.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F4 Represents volume-weighted average price of sales of 27 shares of Company stock on October 14, 2026 at prices ranging from $761.01 to $761.68. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F5 Represents volume-weighted average price of sales of 25 shares of Company stock on October 14, 2026 at prices ranging from $763.62 to $763.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F6 Represents volume-weighted average price of sales of 219 shares of Company stock on October 14, 2026 at prices ranging from $764.04 to $764.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F7 Represents volume-weighted average price of sales of 271 shares of Company stock on October 14, 2026 at prices ranging from $765.11 to $765.78. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F8 Represents volume-weighted average price of sales of 279 shares of Company stock on October 14, 2026 at prices ranging from $766.00 to $766.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F9 Represents volume-weighted average price of sales of 192 shares of Company stock on October 14, 2026 at prices ranging from $767.10 to $767.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F10 Represents volume-weighted average price of sales of 105 shares of Company stock on October 14, 2026 at prices ranging from $768.15 to $768.59. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F11 Represents volume-weighted average price of sales of 127 shares of Company stock on October 14, 2026 at prices ranging from $769.15 to $769.93. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F12 Represents volume-weighted average price of sales of 283 shares of Company stock on October 14, 2026 at prices ranging from $771.04 to $771.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F13 Represents volume-weighted average price of sales of 211 shares of Company stock on October 14, 2026 at prices ranging from $772.06 to $772.74. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F14 Represents volume-weighted average price of sales of 224 shares of Company stock on October 14, 2026 at prices ranging from $773.14 to $773.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F15 Represents volume-weighted average price of sales of 121 shares of Company stock on October 14, 2026 at prices ranging from $774.11 to $774.85. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F16 Represents volume-weighted average price of sales of 376 shares of Company stock on October 14, 2026 at prices ranging from $775.14 to $775.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F17 Represents volume-weighted average price of sales of 66 shares of Company stock on October 14, 2026 at prices ranging from $776.00 to $776.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F18 Represents volume-weighted average price of sales of 38 shares of Company stock on October 14, 2026 at prices ranging from $777.51 to $777.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F19 Represents volume-weighted average price of sales of 454 shares of Company stock on October 14, 2026 at prices ranging from $778.05 to $778.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F20 Represents volume-weighted average price of sales of 380 shares of Company stock on October 14, 2026 at prices ranging from $779.00 to $779.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F21 Represents volume-weighted average price of sales of 463 shares of Company stock on October 14, 2026 at prices ranging from $780.06 to $780.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F22 Represents volume-weighted average price of sales of 50 shares of Company stock on October 14, 2026 at prices ranging from $781.05 to $781.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F23 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F1	S Sale (market/private)Common Stock · Non-derivative	35D	755.91	Direct	Form 4 ↗0001796226-26-000002
2026-10-14Filed 2026-10-15	MURPHY ANDREW JOfficer · Co-Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on May 7, 2026. F2 Represents volume-weighted average price of sales of 14 shares of Company stock on October 14, 2026 at prices ranging from $759.94 to $759.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F3 Represents volume-weighted average price of sales of 74 shares of Company stock on October 14, 2026 at prices ranging from $760.28 to $760.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F4 Represents volume-weighted average price of sales of 27 shares of Company stock on October 14, 2026 at prices ranging from $761.01 to $761.68. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F5 Represents volume-weighted average price of sales of 25 shares of Company stock on October 14, 2026 at prices ranging from $763.62 to $763.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F6 Represents volume-weighted average price of sales of 219 shares of Company stock on October 14, 2026 at prices ranging from $764.04 to $764.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F7 Represents volume-weighted average price of sales of 271 shares of Company stock on October 14, 2026 at prices ranging from $765.11 to $765.78. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F8 Represents volume-weighted average price of sales of 279 shares of Company stock on October 14, 2026 at prices ranging from $766.00 to $766.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F9 Represents volume-weighted average price of sales of 192 shares of Company stock on October 14, 2026 at prices ranging from $767.10 to $767.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F10 Represents volume-weighted average price of sales of 105 shares of Company stock on October 14, 2026 at prices ranging from $768.15 to $768.59. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F11 Represents volume-weighted average price of sales of 127 shares of Company stock on October 14, 2026 at prices ranging from $769.15 to $769.93. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F12 Represents volume-weighted average price of sales of 283 shares of Company stock on October 14, 2026 at prices ranging from $771.04 to $771.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F13 Represents volume-weighted average price of sales of 211 shares of Company stock on October 14, 2026 at prices ranging from $772.06 to $772.74. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F14 Represents volume-weighted average price of sales of 224 shares of Company stock on October 14, 2026 at prices ranging from $773.14 to $773.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F15 Represents volume-weighted average price of sales of 121 shares of Company stock on October 14, 2026 at prices ranging from $774.11 to $774.85. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F16 Represents volume-weighted average price of sales of 376 shares of Company stock on October 14, 2026 at prices ranging from $775.14 to $775.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F17 Represents volume-weighted average price of sales of 66 shares of Company stock on October 14, 2026 at prices ranging from $776.00 to $776.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F18 Represents volume-weighted average price of sales of 38 shares of Company stock on October 14, 2026 at prices ranging from $777.51 to $777.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F19 Represents volume-weighted average price of sales of 454 shares of Company stock on October 14, 2026 at prices ranging from $778.05 to $778.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F20 Represents volume-weighted average price of sales of 380 shares of Company stock on October 14, 2026 at prices ranging from $779.00 to $779.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F21 Represents volume-weighted average price of sales of 463 shares of Company stock on October 14, 2026 at prices ranging from $780.06 to $780.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F22 Represents volume-weighted average price of sales of 50 shares of Company stock on October 14, 2026 at prices ranging from $781.05 to $781.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F23 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F1	S Sale (market/private)Common Stock · Non-derivative	6D	753.76	Direct	Form 4 ↗0001796226-26-000002
2026-10-13Filed 2026-10-15	MURPHY ANDREW JOfficer · Co-Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on May 7, 2026. F2 Represents volume-weighted average price of sales of 14 shares of Company stock on October 14, 2026 at prices ranging from $759.94 to $759.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F3 Represents volume-weighted average price of sales of 74 shares of Company stock on October 14, 2026 at prices ranging from $760.28 to $760.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F4 Represents volume-weighted average price of sales of 27 shares of Company stock on October 14, 2026 at prices ranging from $761.01 to $761.68. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F5 Represents volume-weighted average price of sales of 25 shares of Company stock on October 14, 2026 at prices ranging from $763.62 to $763.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F6 Represents volume-weighted average price of sales of 219 shares of Company stock on October 14, 2026 at prices ranging from $764.04 to $764.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F7 Represents volume-weighted average price of sales of 271 shares of Company stock on October 14, 2026 at prices ranging from $765.11 to $765.78. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F8 Represents volume-weighted average price of sales of 279 shares of Company stock on October 14, 2026 at prices ranging from $766.00 to $766.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F9 Represents volume-weighted average price of sales of 192 shares of Company stock on October 14, 2026 at prices ranging from $767.10 to $767.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F10 Represents volume-weighted average price of sales of 105 shares of Company stock on October 14, 2026 at prices ranging from $768.15 to $768.59. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F11 Represents volume-weighted average price of sales of 127 shares of Company stock on October 14, 2026 at prices ranging from $769.15 to $769.93. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F12 Represents volume-weighted average price of sales of 283 shares of Company stock on October 14, 2026 at prices ranging from $771.04 to $771.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F13 Represents volume-weighted average price of sales of 211 shares of Company stock on October 14, 2026 at prices ranging from $772.06 to $772.74. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F14 Represents volume-weighted average price of sales of 224 shares of Company stock on October 14, 2026 at prices ranging from $773.14 to $773.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F15 Represents volume-weighted average price of sales of 121 shares of Company stock on October 14, 2026 at prices ranging from $774.11 to $774.85. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F16 Represents volume-weighted average price of sales of 376 shares of Company stock on October 14, 2026 at prices ranging from $775.14 to $775.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F17 Represents volume-weighted average price of sales of 66 shares of Company stock on October 14, 2026 at prices ranging from $776.00 to $776.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F18 Represents volume-weighted average price of sales of 38 shares of Company stock on October 14, 2026 at prices ranging from $777.51 to $777.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F19 Represents volume-weighted average price of sales of 454 shares of Company stock on October 14, 2026 at prices ranging from $778.05 to $778.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F20 Represents volume-weighted average price of sales of 380 shares of Company stock on October 14, 2026 at prices ranging from $779.00 to $779.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F21 Represents volume-weighted average price of sales of 463 shares of Company stock on October 14, 2026 at prices ranging from $780.06 to $780.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F22 Represents volume-weighted average price of sales of 50 shares of Company stock on October 14, 2026 at prices ranging from $781.05 to $781.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F23 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F1, F23	M Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative	17,000D	0	Direct	Form 4 ↗0001796226-26-000002
2026-10-13Filed 2026-10-15	MURPHY ANDREW JOfficer · Co-Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on May 7, 2026. F2 Represents volume-weighted average price of sales of 14 shares of Company stock on October 14, 2026 at prices ranging from $759.94 to $759.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F3 Represents volume-weighted average price of sales of 74 shares of Company stock on October 14, 2026 at prices ranging from $760.28 to $760.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F4 Represents volume-weighted average price of sales of 27 shares of Company stock on October 14, 2026 at prices ranging from $761.01 to $761.68. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F5 Represents volume-weighted average price of sales of 25 shares of Company stock on October 14, 2026 at prices ranging from $763.62 to $763.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F6 Represents volume-weighted average price of sales of 219 shares of Company stock on October 14, 2026 at prices ranging from $764.04 to $764.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F7 Represents volume-weighted average price of sales of 271 shares of Company stock on October 14, 2026 at prices ranging from $765.11 to $765.78. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F8 Represents volume-weighted average price of sales of 279 shares of Company stock on October 14, 2026 at prices ranging from $766.00 to $766.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F9 Represents volume-weighted average price of sales of 192 shares of Company stock on October 14, 2026 at prices ranging from $767.10 to $767.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F10 Represents volume-weighted average price of sales of 105 shares of Company stock on October 14, 2026 at prices ranging from $768.15 to $768.59. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F11 Represents volume-weighted average price of sales of 127 shares of Company stock on October 14, 2026 at prices ranging from $769.15 to $769.93. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F12 Represents volume-weighted average price of sales of 283 shares of Company stock on October 14, 2026 at prices ranging from $771.04 to $771.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F13 Represents volume-weighted average price of sales of 211 shares of Company stock on October 14, 2026 at prices ranging from $772.06 to $772.74. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F14 Represents volume-weighted average price of sales of 224 shares of Company stock on October 14, 2026 at prices ranging from $773.14 to $773.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F15 Represents volume-weighted average price of sales of 121 shares of Company stock on October 14, 2026 at prices ranging from $774.11 to $774.85. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F16 Represents volume-weighted average price of sales of 376 shares of Company stock on October 14, 2026 at prices ranging from $775.14 to $775.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F17 Represents volume-weighted average price of sales of 66 shares of Company stock on October 14, 2026 at prices ranging from $776.00 to $776.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F18 Represents volume-weighted average price of sales of 38 shares of Company stock on October 14, 2026 at prices ranging from $777.51 to $777.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F19 Represents volume-weighted average price of sales of 454 shares of Company stock on October 14, 2026 at prices ranging from $778.05 to $778.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F20 Represents volume-weighted average price of sales of 380 shares of Company stock on October 14, 2026 at prices ranging from $779.00 to $779.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F21 Represents volume-weighted average price of sales of 463 shares of Company stock on October 14, 2026 at prices ranging from $780.06 to $780.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F22 Represents volume-weighted average price of sales of 50 shares of Company stock on October 14, 2026 at prices ranging from $781.05 to $781.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F23 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F1	F WithholdingCommon Stock · Non-derivative	12,853D	754.58	Direct	Form 4 ↗0001796226-26-000002
2026-10-13Filed 2026-10-15	MURPHY ANDREW JOfficer · Co-Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on May 7, 2026. F2 Represents volume-weighted average price of sales of 14 shares of Company stock on October 14, 2026 at prices ranging from $759.94 to $759.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F3 Represents volume-weighted average price of sales of 74 shares of Company stock on October 14, 2026 at prices ranging from $760.28 to $760.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F4 Represents volume-weighted average price of sales of 27 shares of Company stock on October 14, 2026 at prices ranging from $761.01 to $761.68. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F5 Represents volume-weighted average price of sales of 25 shares of Company stock on October 14, 2026 at prices ranging from $763.62 to $763.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F6 Represents volume-weighted average price of sales of 219 shares of Company stock on October 14, 2026 at prices ranging from $764.04 to $764.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F7 Represents volume-weighted average price of sales of 271 shares of Company stock on October 14, 2026 at prices ranging from $765.11 to $765.78. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F8 Represents volume-weighted average price of sales of 279 shares of Company stock on October 14, 2026 at prices ranging from $766.00 to $766.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F9 Represents volume-weighted average price of sales of 192 shares of Company stock on October 14, 2026 at prices ranging from $767.10 to $767.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F10 Represents volume-weighted average price of sales of 105 shares of Company stock on October 14, 2026 at prices ranging from $768.15 to $768.59. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F11 Represents volume-weighted average price of sales of 127 shares of Company stock on October 14, 2026 at prices ranging from $769.15 to $769.93. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F12 Represents volume-weighted average price of sales of 283 shares of Company stock on October 14, 2026 at prices ranging from $771.04 to $771.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F13 Represents volume-weighted average price of sales of 211 shares of Company stock on October 14, 2026 at prices ranging from $772.06 to $772.74. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F14 Represents volume-weighted average price of sales of 224 shares of Company stock on October 14, 2026 at prices ranging from $773.14 to $773.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F15 Represents volume-weighted average price of sales of 121 shares of Company stock on October 14, 2026 at prices ranging from $774.11 to $774.85. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F16 Represents volume-weighted average price of sales of 376 shares of Company stock on October 14, 2026 at prices ranging from $775.14 to $775.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F17 Represents volume-weighted average price of sales of 66 shares of Company stock on October 14, 2026 at prices ranging from $776.00 to $776.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F18 Represents volume-weighted average price of sales of 38 shares of Company stock on October 14, 2026 at prices ranging from $777.51 to $777.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F19 Represents volume-weighted average price of sales of 454 shares of Company stock on October 14, 2026 at prices ranging from $778.05 to $778.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F20 Represents volume-weighted average price of sales of 380 shares of Company stock on October 14, 2026 at prices ranging from $779.00 to $779.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F21 Represents volume-weighted average price of sales of 463 shares of Company stock on October 14, 2026 at prices ranging from $780.06 to $780.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F22 Represents volume-weighted average price of sales of 50 shares of Company stock on October 14, 2026 at prices ranging from $781.05 to $781.84. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on October 14, 2026 at each separate price. F23 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F1	M Exercise / conversionCommon Stock · Non-derivative	17,000A	381.92	Direct	Form 4 ↗0001796226-26-000002
2026-09-03Filed 2026-09-03	McCourt MarionOfficer · EVP Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 17, 2026. References: F1	S Sale (market/private)Common Stock · Non-derivative	1,131D	857.39	Direct	Form 4 ↗0001663758-26-000002
2026-09-02Filed 2026-09-03	Guarini KathrynDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 13, 2026. F2 On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant. References: F1, F2	M Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative	400D	0	Direct	Form 4 ↗0001992352-26-000007
2026-09-02Filed 2026-09-03	Guarini KathrynDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 13, 2026. F2 On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant. References: F1	S Sale (market/private)Common Stock · Non-derivative	400D	850	Direct	Form 4 ↗0001992352-26-000007
2026-09-02Filed 2026-09-03	Guarini KathrynDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 13, 2026. F2 On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant. References: F1	M Exercise / conversionCommon Stock · Non-derivative	400A	719.37	Direct	Form 4 ↗0001992352-26-000007
2026-09-02Filed 2026-09-03	McCourt MarionOfficer · EVP Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 17, 2026. References: F1	S Sale (market/private)Common Stock · Non-derivative	1,215D	850	Direct	Form 4 ↗0001663758-26-000002
2026-08-19Filed 2026-08-21	LAROSA JOSEPH JOfficer · EVP General Counsel and Secret Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F1	M Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative	12,282D	0	Direct	Form 4 ↗0001238303-26-000002
2026-08-19Filed 2026-08-21	LAROSA JOSEPH JOfficer · EVP General Counsel and Secret Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References:	F WithholdingCommon Stock · Non-derivative	9,019D	830.15	Direct	Form 4 ↗0001238303-26-000002
2026-08-19Filed 2026-08-21	LAROSA JOSEPH JOfficer · EVP General Counsel and Secret Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References:	M Exercise / conversionCommon Stock · Non-derivative	12,282A	381.92	Direct	Form 4 ↗0001238303-26-000002
2026-08-18Filed 2026-08-20	Fenimore Christopher R.Officer · EVP Finance CFO Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 These shares are held in a trust for the benefit of the reporting person's spouse. The reporting person and the reporting person's spouse are trustees of the trust. F2 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References: F2	M Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative	6,283D	0	Direct	Form 4 ↗0001697422-26-000002
2026-08-18Filed 2026-08-20	Fenimore Christopher R.Officer · EVP Finance CFO Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 These shares are held in a trust for the benefit of the reporting person's spouse. The reporting person and the reporting person's spouse are trustees of the trust. F2 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References:	F WithholdingCommon Stock · Non-derivative	4,599D	813.47	Direct	Form 4 ↗0001697422-26-000002
2026-08-18Filed 2026-08-20	Fenimore Christopher R.Officer · EVP Finance CFO Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 These shares are held in a trust for the benefit of the reporting person's spouse. The reporting person and the reporting person's spouse are trustees of the trust. F2 The stock option award vested in four equal annual installments, commencing one year after the date of grant. References:	M Exercise / conversionCommon Stock · Non-derivative	6,283A	381.92	Direct	Form 4 ↗0001697422-26-000002
2026-08-10Filed 2026-08-12	Guarini KathrynDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 13, 2026. F2 On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant. References: F1, F2	M Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative	400D	0	Direct	Form 4 ↗0001992352-26-000005
2026-08-10Filed 2026-08-12	Guarini KathrynDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 13, 2026. F2 On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant. References: F1	S Sale (market/private)Common Stock · Non-derivative	400D	800	Direct	Form 4 ↗0001992352-26-000005
2026-08-10Filed 2026-08-12	Guarini KathrynDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on February 13, 2026. F2 On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant. References: F1	M Exercise / conversionCommon Stock · Non-derivative	400A	719.37	Direct	Form 4 ↗0001992352-26-000005
2026-08-10Filed 2026-08-12	Zoghbi Huda YDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on November 20, 2025. F2 The stock option vested in three equal annual installments, commencing one year after the date of grant. References: F1, F2	M Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative	800D	0	Direct	Form 4 ↗0001681643-26-000006
2026-08-10Filed 2026-08-12	Zoghbi Huda YDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on November 20, 2025. F2 The stock option vested in three equal annual installments, commencing one year after the date of grant. References: F1	S Sale (market/private)Common Stock · Non-derivative	800D	800	Direct	Form 4 ↗0001681643-26-000006
2026-08-10Filed 2026-08-12	Zoghbi Huda YDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on November 20, 2025. F2 The stock option vested in three equal annual installments, commencing one year after the date of grant. References: F1	M Exercise / conversionCommon Stock · Non-derivative	800A	376.69	Direct	Form 4 ↗0001681643-26-000006
2026-07-02Filed 2026-07-07	RYAN ARTHUR FDirector Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c) adopted on October 31, 2025. F2 Represents volume-weighted average price of sales of 200 shares of Company stock on July 2, 2026 at prices ranging from $650.10 to $650.19. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 2, 2026 at each separate price. References: F1, F2	S Sale (market/private)Common Stock · Non-derivative	200D	650.15	Direct	Form 4 ↗0001187443-26-000010

Imported instruments only. Joint owners do not multiply transactions. Amendments are separate filing rows, not additional trades. No aggregate trade totals are implied.