SEC INSIDER TRANSACTIONS

INCYTE CORP (INCY) Insider Transactions

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INCY · INCYTE CORP

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OR within codes/roles; AND between categories. Roles apply to buyers and sellers. Owner predicates match the same owner. Missing values fail numeric/date filters. Value is quantity × reported price for non-derivative rows only; derivative values are unknown. Amendments stay separate; joint owners do not duplicate rows.

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Stale snapshot · Covered: filings 2026-05-14 to 2026-11-13 · 53 filings · fetched 2026-11-13T18:19:43Z

Recent reported activity

0purchase rows on this page

2sale rows on this page

194matching filing rows

Purchases and sales count original non-derivative P and S rows. Awards, gifts, exercises, derivatives and amendments are shown separately and are not described as market purchases.

Transaction / filed	Reporting owner(s)	Code / security	Quantity	Price as filed	Ownership	Source
2026-07-16Filed 2026-07-20	Basi Ramitpal KOfficer · EVP, Human Resources Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 11,497 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F4	A Award / grantEmployee Stock Option (right to buy) · Derivative	21,548A	0	Direct	Form 4 ↗0002083591-26-000005
2026-07-16Filed 2026-07-20	Basi Ramitpal KOfficer · EVP, Human Resources Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 11,497 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantPerformance Shares · Derivative	12,479A	0	Direct	Form 4 ↗0002083591-26-000005
2026-07-16Filed 2026-07-20	Basi Ramitpal KOfficer · EVP, Human Resources Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 11,497 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	4,991A	0	Direct	Form 4 ↗0002083591-26-000005
2026-07-16Filed 2026-07-20	Mayes Patrick AOfficer · EVP & Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 74,327 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F4	A Award / grantEmployee Stock Option (right to buy) · Derivative	25,538A	0	Direct	Form 4 ↗0002079962-26-000011
2026-07-16Filed 2026-07-20	Mayes Patrick AOfficer · EVP & Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 74,327 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantPerformance Shares · Derivative	14,790A	0	Direct	Form 4 ↗0002079962-26-000011
2026-07-16Filed 2026-07-20	Mayes Patrick AOfficer · EVP & Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 74,327 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	5,916A	0	Direct	Form 4 ↗0002079962-26-000011
2026-07-16Filed 2026-07-20	Issa Mohamed KhairieOfficer · EVP, Head of U.S. Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 71,797 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F4	A Award / grantEmployee Stock Option (right to buy) · Derivative	33,918A	0	Direct	Form 4 ↗0002050035-26-000011
2026-07-16Filed 2026-07-20	Issa Mohamed KhairieOfficer · EVP, Head of U.S. Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 71,797 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantPerformance Shares · Derivative	19,643A	0	Direct	Form 4 ↗0002050035-26-000011
2026-07-16Filed 2026-07-20	Issa Mohamed KhairieOfficer · EVP, Head of U.S. Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 71,797 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	7,857A	0	Direct	Form 4 ↗0002050035-26-000011
2026-07-16Filed 2026-07-20	Issa Mohamed KhairieOfficer · EVP, Head of U.S. Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 71,797 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References:	S Sale (market/private)Common Stock · Non-derivative	1,093D	115.01	Direct	Form 4 ↗0002050035-26-000011
2026-07-16Filed 2026-07-20	Tray ThomasOfficer · Principal Accounting Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 13,070 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantEmployee Stock Option (right to buy) · Derivative	4,079A	0	Direct	Form 4 ↗0001912317-26-000015
2026-07-16Filed 2026-07-20	Tray ThomasOfficer · Principal Accounting Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 13,070 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. F3 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	2,834A	0	Direct	Form 4 ↗0001912317-26-000015
2026-07-16Filed 2026-07-20	Stein Steven HOfficer · CMO & Head of Late-Stage Dev. Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 29,338 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F4	A Award / grantEmployee Stock Option (right to buy) · Derivative	42,298A	0	Direct	Form 4 ↗0001673776-26-000019
2026-07-16Filed 2026-07-20	Stein Steven HOfficer · CMO & Head of Late-Stage Dev. Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 29,338 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantPerformance Shares · Derivative	24,496A	0	Direct	Form 4 ↗0001673776-26-000019
2026-07-16Filed 2026-07-20	Stein Steven HOfficer · CMO & Head of Late-Stage Dev. Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 29,338 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	9,798A	0	Direct	Form 4 ↗0001673776-26-000019
2026-07-16Filed 2026-07-20	Stein Steven HOfficer · CMO & Head of Late-Stage Dev. Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 29,338 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References:	S Sale (market/private)Common Stock · Non-derivative	1,877D	114.73	Direct	Form 4 ↗0001673776-26-000019
2026-07-16Filed 2026-07-20	Meury WilliamDirector · Officer · Chief Executive Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 178,883 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F4	A Award / grantEmployee Stock Option (right to buy) · Derivative	77,148A	0	Direct	Form 4 ↗0001536778-26-000009
2026-07-16Filed 2026-07-20	Meury WilliamDirector · Officer · Chief Executive Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 178,883 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantPerformance Shares · Derivative	80,421A	0	Direct	Form 4 ↗0001536778-26-000009
2026-07-16Filed 2026-07-20	Meury WilliamDirector · Officer · Chief Executive Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 178,883 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	26,807A	0	Direct	Form 4 ↗0001536778-26-000009
2026-07-16Filed 2026-07-20	CAGNONI PABLO JOfficer · President, Global Head of R&D Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 183,200 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F4	A Award / grantEmployee Stock Option (right to buy) · Derivative	57,861A	0	Direct	Form 4 ↗0001205703-26-000021
2026-07-16Filed 2026-07-20	CAGNONI PABLO JOfficer · President, Global Head of R&D Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 183,200 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F3	A Award / grantPerformance Shares · Derivative	33,508A	0	Direct	Form 4 ↗0001205703-26-000021
2026-07-16Filed 2026-07-20	CAGNONI PABLO JOfficer · President, Global Head of R&D Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis. F2 Including the July 16, 2026 grant, this includes an aggregate of 183,200 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. F3 Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ("TSR") over a three-year performance period beginning on January 1, 2026 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date subject to the Reporting Person's continued service with the issuer. F4 The July 16, 2026 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years. Remarks: References: F1, F2	A Award / grantCommon Stock · Non-derivative	13,403A	0	Direct	Form 4 ↗0001205703-26-000021
2026-07-15Filed 2026-07-16	Mayes Patrick AOfficer · EVP & Chief Scientific Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock. F2 Includes an aggregate of 53,621 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. References: F1, F2	F WithholdingCommon Stock · Non-derivative	1,512D	115.09	Direct	Form 4 ↗0002079962-26-000009
2026-07-15Filed 2026-07-16	Issa Mohamed KhairieOfficer · EVP, Head of U.S. Commercial Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock. F2 This includes an aggregate of 63,940 shares of common stock issuable pursuant to previously reported RSUs that have not vested. References: F1, F2	F WithholdingCommon Stock · Non-derivative	1,099D	115.09	Direct	Form 4 ↗0002050035-26-000009
2026-07-15Filed 2026-07-16	Tray ThomasOfficer · Principal Accounting Officer Filing context Reported filing row; may be amended. Do not sum filings blindly. F1 Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units previously reported in Table I as common stock. F2 This includes an aggregate of 10,236 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. References: F1, F2	F WithholdingCommon Stock · Non-derivative	1,098D	115.09	Direct	Form 4 ↗0001912317-26-000013

Imported instruments only. Joint owners do not multiply transactions. Amendments are separate filing rows, not additional trades. No aggregate trade totals are implied.